It was concluded that women with atrial fibrillation have a moderately increased risk of stroke compared with men, and thus, female sex should be considered when making decisions about anticoagulation treatment. After adjustment for 35 co-risk factors for stroke, an increased risk of stroke in women remained (1.18, 1.12 to 1.24). means Research that is not conducted in connection with Treatment and involves the use of Protected Health Information that relates to Treatment provided prior to the date on which the Research proposal is submitted to an Institutional Review Board. The unadjusted hazard ratio of ischaemic stroke for women compared with men was 1.47 (95% confidence 1.40 to 1.54). You will need to submit a modification stating you are conducting a retrospective and prospective chart review and if the study was initially reviewed as exempt, it will now need to be reviewed as expedited. It was reported that ischaemic strokes were more common in women than in men (6.2% v 4.2% per year P<0.0001). retrospective chart review since all the data was not in existence at the time of INITIAL IRB submission on 3/18/15.
The primary outcome measure was the occurrence of ischaemic stroke. Patients who died less than 14 days from baseline were also excluded. Patients were excluded if at baseline they were prescribed warfarin, had mitral stenosis, or had previous valvular surgery. Information about drug treatment was taken from the Swedish drug register. Participants were 100 802 patients with a first diagnosis of atrial fibrillation between 1 July 2005 and 31 December 2008, with a total follow-up of 139 504 years at risk (median 1.2). Data were taken from the Swedish national discharge register. 1 A nationwide retrospective cohort study design was used.
Researchers investigated whether differences exist between the sexes in the risk of ischaemic stroke in patients with atrial fibrillation.
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